Quantitative Systems Toxicology (QST) involves leveraging mathematical and computational modeling approaches to provide predictive tools that aid improved toxicity assessments. Our team provides a full spectrum of modeling services that incorporates mechanistic information from toxicogenomics data, in addition to the existing scientific literature and available toxicity databases, to determine predictive, quantitative relationships for how chemicals in the environment lead to an adverse outcome for individual and populations of wildlife animals that serve as ecological indicators of environmental health. Services include:

  • Data curation (scientific literature, database, etc.)
  • Mathematical model development (ADME, toxicokinetics, toxicodynamics, qAOPs, etc.)
  • Model analysis, evaluation, and validation
  • Graphical user interface (GUI) and software development for improved end-user experience
  • High quality report generation

Products from our QST services have been used by governmental organizations ranging from the US Army Corps of Engineers (USACE) to the US Environmental Protection Agency (USEPA).